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The pharmacology instructor is discussing the differences among the various diuretic agents. Which would the instructor cite as a difference between spironolactone and hydrochlorothiazide?a. Potassium losses are greater with spironolactone than with hydrochlorothiazide.b. Potassium losses are greater with hydrochlorothiazide than with spironolactone.c. Spironolactone is more likely to be taken with a potassium supplement.d. The two diuretics act in different parts of the nephron

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Answer:

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The answer is b. Potassium losses are greater with hydrochlorothiazide than with spironolactone.

Explanation:

Hydrochlorothiazide and spironolactone is a drug combination prescribed to treat edema, congestive heart failure and nephrotic syndrome.

  • Hydrochlorothiazide and Spironolactone both help prevent fluid retention in the body by preventing excessive absorption of salt. Therefore, both of these drugs would ultimately cause salt or potassium losses.
  • Unlike hydrochlorothiazide, spironolactone, being a potassium sparring diuretic (a drug that increases urination without the loss of potassium), prevents potassium levels in the body from getting too low.
  • Since spironolactone is a potassium sparring drug, it should never be taken with a potassium supplement as it can lead to hyperkalemia (excess potassium).
  • Both diuretics act in the same part of the nephron, the distal tubule.

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